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Volume 168, Issue 11

Structural and functional characteristics of the tripartite ABC transporter Open Access

This article is part of the Antimicrobial Efflux collection.

Abstract

ATP-binding cassette (ABC) transporters are one of the largest protein superfamilies and are found in all living organisms. These transporters use the energy from ATP binding and hydrolysis to transport various substrates. In this review, we focus on the structural and functional aspects of ABC transporters, with special emphasis on type VII ABC transporters, a newly defined class possessing characteristic structures. A notable feature of type VII ABC transporters is that they assemble into tripartite complexes that span both the inner and outer membranes of Gram-negative bacteria. One of the original type VII ABC transporters, which possesses all characteristic features of this class, is the macrolide efflux transporter MacB. Recent structural analyses of MacB and homologue proteins revealed the unique mechanisms of substrate translocation by type VII ABC transporters.

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  • Accepted:
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Keyword(s): ABC transporter , Lol system , macrolide resistance , structural biology and tripartite efflux pump
© 2022 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2022-11-21
2024-05-04
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Structural and functional characteristics of the tripartite ABC transporter
Microbiology 168, 001257 (2022); https://doi.org/10.1099/mic.0.001257
/content/journal/micro/10.1099/mic.0.001257
/content/journal/micro/10.1099/mic.0.001257
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