SUMMARY: The relationship between genes and enzymes in the methionine biosynthetic pathway has been studied in The first step is catalysed by an -succinylhomoserine synthase, the product of the gene mapped at 20 min on the chromosome. The second step is achieved by direct sulfhydrylation, involving the enzyme encoded by a gene that we have identified and sequenced, located at 40 min. Thus appears to be the only organism so far described that uses -succinylhomoserine as substrate for a direct sulfhydrylation. As in yeast, the two transsulfuration pathways between cysteine and homocysteine, with cystathionine as an intermediate, probably exist in parallel in this organism.


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