@article{mbs:/content/journal/micro/10.1099/13500872-141-2-431, author = "Foglino, M. and Borne, F. and Bally, M. and Ball, G. and Patte, J. C.", title = "A direct sulfhydrylation pathway is used for methionine biosynthesis in Pseudomonas aeruginosa", journal= "Microbiology", year = "1995", volume = "141", number = "2", pages = "431-439", doi = "https://doi.org/10.1099/13500872-141-2-431", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/13500872-141-2-431", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", keywords = "methionine biosynthesis", keywords = "sulfhydrylation", keywords = "Pseudomonas", abstract = "SUMMARY: The relationship between genes and enzymes in the methionine biosynthetic pathway has been studied in Pseudomonas aeruginosa. The first step is catalysed by an O-succinylhomoserine synthase, the product of the metA gene mapped at 20 min on the chromosome. The second step is achieved by direct sulfhydrylation, involving the enzyme encoded by a metZ gene that we have identified and sequenced, located at 40 min. Thus Pseudomonas appears to be the only organism so far described that uses O-succinylhomoserine as substrate for a direct sulfhydrylation. As in yeast, the two transsulfuration pathways between cysteine and homocysteine, with cystathionine as an intermediate, probably exist in parallel in this organism.", }