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Summary: The R factor pMG2 protects Pseudomonas aeruginosa against the lethal effects of ultraviolet (u.v.) and gamma irradiation, and methyl methanesulphonate and N-methyl-N′-nitro-N-nitrosoguanidine treatment. Enhanced survival occurs in strains of uvr + rec + (wild-type) genotype and a variety of uvr rec + type mutants. No protection occurs in a recA-type mutant. The plasmid also enhances u.v.-induced mutagenesis. These effects appear to be due to host-cell controlled plsmid-determined DNA repair function(s). Studies on P. aeruginosa strains deficient in DNA polymerase I (polA) suggest that a plasmid-determined repair resynthesis function may be responsible for increased u.v.-survival and enhanced u.v.-mutability in pMG2-containing bacteria.
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