SUMMARY: The R factor pMG2 protects against the lethal effects of ultraviolet (u.v.) and gamma irradiation, and methyl methanesulphonate and -methyl--nitro--nitrosoguanidine treatment. Enhanced survival occurs in strains of (wild-type) genotype and a variety of type mutants. No protection occurs in a -type mutant. The plasmid also enhances u.v.-induced mutagenesis. These effects appear to be due to host-cell controlled plsmid-determined DNA repair function(s). Studies on strains deficient in DNA polymerase I () suggest that a plasmid-determined repair resynthesis function may be responsible for increased u.v.-survival and enhanced u.v.-mutability in pMG2-containing bacteria.


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