%0 Journal Article %A Lehrbach, P. %A Kung, A. H. C. %A Lee, B. T. O. %A Jacoby, G. A. %T Plasmid Modification of Radiation and Chemical-mutagen Sensitivity in Pseudomonas aeruginosa %D 1977 %J Microbiology, %V 98 %N 1 %P 167-176 %@ 1465-2080 %R https://doi.org/10.1099/00221287-98-1-167 %I Microbiology Society, %X Summary: The R factor pMG2 protects Pseudomonas aeruginosa against the lethal effects of ultraviolet (u.v.) and gamma irradiation, and methyl methanesulphonate and N-methyl-N′-nitro-N-nitrosoguanidine treatment. Enhanced survival occurs in strains of uvr + rec + (wild-type) genotype and a variety of uvr rec + type mutants. No protection occurs in a recA-type mutant. The plasmid also enhances u.v.-induced mutagenesis. These effects appear to be due to host-cell controlled plsmid-determined DNA repair function(s). Studies on P. aeruginosa strains deficient in DNA polymerase I (polA) suggest that a plasmid-determined repair resynthesis function may be responsible for increased u.v.-survival and enhanced u.v.-mutability in pMG2-containing bacteria. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-98-1-167