Summary: The antimycobacterial activity of a new series of 2-acetylpyridine thiosemicarbazones was determined using ATCC 607. The resulting log minimal inhibitory concentration (μmol l) values were plotted against the partition coefficient (log ) values for each compound, and fell on a parabolic distribution curve having a log of 3.0. Compounds having partition coefficients outside the range 2.0 to 4.0 were inactive against . When similar assays were carried out using and , a similar series of parabolic activity curves were obtained having log values around 4.0. The significance of this shift in the log value obtained using the slow-growing pathogenic mycobacteria compared to that observed with the rapid-growing is discussed in relation to the structures of the variable substituents of these new 2-acetylpyridine thiosemicarbazone compounds.


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