1887

Abstract

infections have grown in importance in the last years. However, most of the studies have focused on , the most prevalent species in the genus. In certain locales and hospitals, is more common in air than , for unclear reasons. After , is the second leading cause of invasive aspergillosis and it is the most common cause of superficial infection. Experimental invasive infections in mice show to be 100-fold more virulent than in terms of inoculum required. Particularly common clinical syndromes associated with include chronic granulomatous sinusitis, keratitis, cutaneous aspergillosis, wound infections and osteomyelitis following trauma and inoculation. Outbreaks associated with appear to be associated with single or closely related strains, in contrast to those associated with . In addition, produces aflatoxins, the most toxic and potent hepatocarcinogenic natural compounds ever characterized. Accurate species identification within complex remains difficult due to overlapping morphological and biochemical characteristics, and much taxonomic and population genetics work is necessary to better understand the species and related species. The complex currently includes 23 species or varieties, including two sexual species, and . The genome of the highly related is completed and available; that of in the final stages of annotation. Our understanding of lags far behind that of . Studies of the genomics, taxonomy, population genetics, pathogenicity, allergenicity and antifungal susceptibility of are all required.

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2007-06-01
2020-09-20
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