RT Journal Article SR Electronic(1) A1 Collins, Frank M. A1 Klayman, Daniel L. A1 Morrison, Norman E.YR 1982 T1 Correlations between Structure and Antimycobacterial Activity in a Series of 2-Acetylpyridine Thiosemicarbazones JF Microbiology, VO 128 IS 6 SP 1349 OP 1356 DO https://doi.org/10.1099/00221287-128-6-1349 PB Microbiology Society, SN 1465-2080, AB The antimycobacterial activity of a new series of 2-acetylpyridine thiosemicarbazones was determined in vitro using Mycobacterium smegmatis ATCC 607. The resulting log minimal inhibitory concentration (μmol l−1) values were plotted against the partition coefficient (log P) values for each compound, and fell on a parabolic distribution curve having a log P opt of 3.0. Compounds having partition coefficients outside the range 2.0 to 4.0 were inactive against M. smegmatis. When similar assays were carried out using M. tuberculosis, M. kansasii, M. marinum, M. simiae, M. avium and M. intracellulare, a similar series of parabolic activity curves were obtained having log P opt values around 4.0. The significance of this shift in the log P opt value obtained using the slow-growing pathogenic mycobacteria compared to that observed with the rapid-growing M. smegmatis is discussed in relation to the structures of the variable substituents of these new 2-acetylpyridine thiosemicarbazone compounds., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-128-6-1349