1887

Abstract

The mode of action of nosiheptide (multhiomycin) on bacterial protein synthesis is closely similar to that of thiostrepton. Both antibiotics inhibit functions of elongation factors Tu and G and greatly reduce the synthesis of guanosine penta- and tetraphosphates in response to stringent factor. Furthermore, the actinomycetes which produce these antibiotics defend themselves against their products in similar fashion. This involves specific pentose-methylation of 23S ribosomal RNA.

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/content/journal/micro/10.1099/00221287-126-1-185
1981-09-01
2019-10-21
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-126-1-185
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