@article{mbs:/content/journal/micro/10.1099/00221287-126-1-185, author = "Cundliffe, Eric and Thompson, Jill", title = "The Mode of Action of Nosiheptide (Multhiomycin) and the Mechanism of Resistance in the Producing Organism", journal= "Microbiology", year = "1981", volume = "126", number = "1", pages = "185-192", doi = "https://doi.org/10.1099/00221287-126-1-185", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-126-1-185", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "The mode of action of nosiheptide (multhiomycin) on bacterial protein synthesis is closely similar to that of thiostrepton. Both antibiotics inhibit functions of elongation factors Tu and G and greatly reduce the synthesis of guanosine penta- and tetraphosphates in response to stringent factor. Furthermore, the actinomycetes which produce these antibiotics defend themselves against their products in similar fashion. This involves specific pentose-methylation of 23S ribosomal RNA.", }