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Volume 71, Issue 10

type f in the post- type b vaccination era: a systematic review Open Access

Abstract

Since the introduction of (Hi) serotype b (Hib) vaccination, reports of increasing incidence rates of non-Hib serotypes have emerged. A systematic review was performed to investigate whether the Hi serotype f (Hif) incidence rate has increased globally and to describe its associated disease burden. In the post-Hib vaccine era, evidence shows that the incidence rate of Hif infection is increasing worldwide. In total 94 studies including 2 701 patients reported Hif infections. The estimated pooled incidence rate of Hif infection was 0.15/100 000 population per year (range: 0.05–0.40/100 000), with a median case fatality ratio of 14.3 %. Invasive infections most frequently presented as pneumonia (45 %), septicaemia (34 %) and meningitis (20 %). Of 191 Hif isolates, 87 % were ampicillin-susceptible. Multi-locus sequence typing revealed that Hif were relatively clonal, with the majority belonging to clonal complex 124. Hif causes invasive infections of significant variance in both severity and presentation. Globally, the Hif population shows little genetic variability and currently appears to possess low resistance to antimicrobials.

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Keyword(s): ampicillin resistance , Haemophilus influenzae serotype f , Hib vaccine , Hif and non-typeable Haemophilus influenzae
© 2022 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2022-10-28
2024-05-02
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Haemophilus influenzae type f in the post-Haemophilus influenzae type b vaccination era: a systematic review
J. Med. Microbiol. 71, 001606 (2022); https://doi.org/10.1099/jmm.0.001606
/content/journal/jmm/10.1099/jmm.0.001606
/content/journal/jmm/10.1099/jmm.0.001606
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