1887

Abstract

Systematic inactivation of genes has previously revealed that 271 are indispensable for growth. In the present study, 11 of these (, , , , , , , , , and ) were identified as genes encoding proteins of unknown function. By analysing the effects of protein depletion, and examining the subcellular localization of these proteins, a start has been made in elucidating their functions. It was found that four of these genes (, , and ) were not required for viability. Analysis of the localization of YkqC suggests that it co-localizes with ribosomes, and it is proposed that it is involved in processing either rRNA or specific mRNAs when they are associated with the ribosome. The results suggest that other novel essential proteins may be involved in lipid synthesis and control of cell wall synthesis.

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2006-10-01
2019-10-17
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