1887

Abstract

A range of properties, including the ability to utilize various sugars, bind macromolecules and produce mutacins, are known to vary in their occurrence in different strains of . In addition, insertion-sequence elements show a limited distribution and sequencing of the genome of UA159 has revealed the presence of putative genomic islands of atypical base composition indicative of foreign DNA. PCR primers flanking regions suspected of having inserted DNA were designed on the basis of the genome sequence of UA159 and used to explore variation in a collection of 39 strains isolated in various parts of the world over the last 40 years. Extensive differences between strains were detected, and similar insertion/deletion events appear to be present in the genomes of strains with very different origins. In two instances, insertion of foreign DNA appears to have displaced original genes. Together with previous results on the occurrence of deletions in genes associated with sugar metabolism, the results indicate that has a core genome and a dispensable genome, and that dispensable genes have become widely distributed through horizontal transfer.

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2006-06-01
2020-04-08
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