1887

Abstract

serovar Typhimurium can be internalized by immature dendritic cells (DCs). The interacting host and bacterial molecules initiating this process remain uncharacterized. The objective of this study was to investigate whether specific fimbriae are involved in the early step of binding and uptake of by DCs. Type 1 fimbriated serovar Typhimurium or recombinant expressing the type 1 fimbriae showed a significantly greater ability to attach to murine bone-marrow-derived DCs than non-fimbriated bacteria. The FimH adhesin was required for efficient interactions with DCs, since fimbriated mutants were impaired in both binding and internalization. Finally, the internalization involved a FimH-dependent process but did not require , a gene essential for -mediated invasion of mammalian epithelial cells. Collectively, these data suggest that the bacterial interaction of DCs through the type 1 fimbrial adhesin FimH is sufficient to target serovar Typhimurium for cellular uptake.

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2007-04-01
2019-10-19
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