1887

Abstract

is an opportunistic pathogen responsible for nosocomial infections. Lipoproteins in Gram-positive bacteria are translocated across the plasma membrane and anchored by the fatty acid group. They perform critical roles, with some described as virulence determinants. The aim of this study was to explore the roles of lipoproteins in the stress response and virulence. We constructed a mutant affected in the predicted prolipoprotein diacylglyceryl transferase gene , and examined the role of Lgt in membrane anchoring, growth, the stress response and virulence. Inactivation of enhanced growth in a high concentration of Mn or under oxidative stress , and significantly decreased virulence.

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2012-03-01
2020-07-02
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