1887

Abstract

Microbial competition exists in the general environment, such as soil or aquatic habitats, upon or within unicellular or multicellular eukaryotic life forms. The molecular actions that govern microbial competition, leading to niche establishment and microbial monopolization, remain undetermined. The emerging technology of imaging mass spectrometry (IMS) enabled the observation that there is directionality in the metabolic output of the organism when co-cultured with . The directionally released antibiotic alters virulence factor production and colonization. Therefore, IMS provides insight into the largely hidden nature of competitive microbial encounters and niche establishment, and provides a paradigm for future antibiotic discovery.

Funding
This study was supported by the:
  • NIH Haemoglobin and Blood Protein Chemistry Training Program (Award 5T32DK007233-34)
  • NIH (Award R01 GM094802 and R01 GM086283)
  • A. P. Gianinni Medical Research Foundation
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/content/journal/micro/10.1099/mic.0.048736-0
2011-09-01
2024-11-13
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