1887

Abstract

is a motile Gram-negative bacterium that colonizes and persists in the human gastric mucosa. The flagellum gene regulatory circuitry of is unique in many aspects compared with the paradigms, and some regulatory checkpoints remain unclear. FliK controls the hook length during flagellar assembly. Microarray analysis of a -null mutant revealed increased transcription of genes under the control of the sigma factor RpoN. This sigma factor has been shown to be responsible for transcription of the class II flagellar genes, including and . No genes higher in the flagellar hierarchy had altered expression, suggesting specific and localized FliK-dependent feedback on the RpoN regulon. FliK thus appears to be involved in three processes: hook-length control, export substrate specificity and control of RpoN transcriptional activity.

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2009-06-01
2020-04-01
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