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Volume 169, Issue 1

Do mitochondria use efflux pumps to protect their ribosomes from antibiotics? Open Access

This article is part of the Antimicrobial Efflux collection.

Abstract

Fungal environments are rich in natural and engineered antimicrobials, and this, combined with the fact that fungal genomes are rich in coding sequences for transporters, suggests that fungi are an intriguing group in which to search for evidence of antimicrobial efflux pumps in mitochondria. Herein, the range of protective mechanisms used by fungi against antimicrobials is introduced, and it is hypothesized, based on the susceptibility of mitochondrial and bacterial ribosomes to the same antibiotics, that mitochondria might also contain pumps that efflux antibiotics from these organelles. Preliminary evidence of ethidium bromide efflux is presented and several candidate efflux pumps are identified in fungal mitochondrial proteomes.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): ABC transporters , MFS transporters , mitochondria drug efflux , mitochondrial ribosomes , Neurospora crassa and Saccharomyces cerevisiae
Funding
This study was supported by the:
  • Natural Sciences and Engineering Research Council of Canada (Award RGPIN-05930-2016)
    • Principle Award Recipient: DeborahA. Court
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2023-01-18
2024-05-08
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Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?
Microbiology 169, 001272 (2023); https://doi.org/10.1099/mic.0.001272
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