1887

Abstract

bacteraemia (SAB) is a major cause of blood-stream infection (BSI) in both healthcare and community settings. While the underlying comorbidities of a patient significantly contributes to their susceptibility to and outcome following SAB, recent studies show the importance of the level of cytolytic toxin production by the infecting bacterium. In this study we demonstrate that this cytotoxicity can be determined directly from the diagnostic MALDI-TOF mass spectrum generated in a routine diagnostic laboratory. With further development this information could be used to guide the management and improve the outcomes for SAB patients.

Funding
This study was supported by the:
  • Health Data Research UK
    • Principle Award Recipient: AndrewW Dowsey
  • Medical Research Council (Award MR/T005408/1)
    • Principle Award Recipient: PhilipWilliams
  • Showering Fund (Award SF124)
    • Principle Award Recipient: MahableshwarAlbur
  • Wellcome Trust (Award 212258/Z/18/Z)
    • Principle Award Recipient: RuthC. Massey
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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/content/journal/micro/10.1099/mic.0.001223
2022-08-23
2024-05-05
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