1887

Abstract

was originally cultured from tropical marine sediments and described as the first obligate marine actinomycete genus. Soon after its discovery, it yielded the potent proteasome inhibitor salinosporamide A, a structurally novel natural product that is currently in phase III clinical trials for the treatment of cancer. If approved, it will be the first natural product derived from a cultured marine microbe to achieve clinical relevance. produces many other biologically active natural products, including some linked to chemical defence, thus providing ecological context for their production. However, genomic analyses reveal that most natural product biosynthetic gene clusters remain orphan, suggesting that more compounds await discovery. The abundance of biosynthetic gene clusters in supports the concept that the small molecules they encode serve important ecological functions, while their evolutionary histories suggest a potential role in promoting diversification. Better insights into the ecological functions of microbial natural products will help inform future discovery efforts.

Funding
This study was supported by the:
  • National Institute of General Medical Sciences (Award R01GM085770)
    • Principle Award Recipient: PaulR. Jensen
Loading

Article metrics loading...

/content/journal/micro/10.1099/mic.0.001163
2022-04-05
2022-05-18
Loading full text...

Full text loading...

References

  1. Udwary DW, Zeigler L, Asolkar RN, Singan V, Lapidus A et al. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci U S A 2007; 104:10376–10381 [View Article] [PubMed]
    [Google Scholar]
  2. Letzel A-C, Li J, Amos GCA, Millán-Aguiñaga N, Ginigini J et al. Genomic insights into specialized metabolism in the marine actinomycete Salinispora. Environ Microbiol 2017; 19:3660–3673 [View Article] [PubMed]
    [Google Scholar]
  3. Amos GCA, Awakawa T, Tuttle RN, Letzel A-C, Kim MC et al. Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality. Proc Natl Acad Sci U S A 2017; 114:E11121–E11130 [View Article] [PubMed]
    [Google Scholar]
  4. Ziemert N, Lechner A, Wietz M, Millán-Aguiñaga N, Chavarria KL et al. Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Proc Natl Acad Sci U S A 2014; 111:E1130–9 [View Article] [PubMed]
    [Google Scholar]
  5. Chase AB, Sweeney D, Muskat MN, Guillén-Matus DG, Jensen PR. Vertical inheritance facilitates interspecies diversification in biosynthetic gene clusters and specialized metabolites. mBio 2021; 12:e02700–21 [View Article] [PubMed]
    [Google Scholar]
  6. Román-Ponce B, Millán-Aguiñaga N, Guillen-Matus D, Chase AB, Ginigini JGM et al. Six novel species of the obligate marine actinobacterium Salinispora, Salinispora cortesiana sp. nov., Salinispora fenicalii sp. nov., Salinispora goodfellowii sp. nov., Salinispora mooreana sp. nov., Salinispora oceanensis sp. nov. and Salinispora vitiensis sp. nov., and emended description of the genus Salinispora. Int J Syst Evol Microbiol 2020; 70:4668–4682 [View Article]
    [Google Scholar]
  7. Jensen PR, Moore BS, Fenical W. The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. Nat Prod Rep 2015; 32:738–751 [View Article] [PubMed]
    [Google Scholar]
  8. Patin NV, Duncan KR, Dorrestein PC, Jensen PR. Competitive strategies differentiate closely related species of marine actinobacteria. ISME J 2016; 10:478–490 [View Article] [PubMed]
    [Google Scholar]
  9. Tuttle RN, Rouse GW, Castro-Falcón G, Hughes CC, Jensen PR. Specialized metabolite-mediated predation defense in the marine actinobacterium Salinispora. Appl Environ Microbiol 2022; 88:AEM [View Article] [PubMed]
    [Google Scholar]
  10. Chhun A, Sousoni D, Aguiló-Ferretjans MDM, Song L, Corre C et al. Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica. Microb Biotechnol 2021; 14:291–306 [View Article] [PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/mic.0.001163
Loading

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error