1887

Abstract

is a lethal fungus disguised in a polysaccharide coat. It can remain dormant in the host for decades prior to reactivation, causing systemic cryptococcosis in humans and other mammals. deploys a multitude of traits to adapt to and survive within the host, including immunosuppression, an ability to replicate intra- and extra-cellularly in phagocytes, changes in morphology and ploidy, a predilection to infect the CNS, and the capacity to utilize neurotransmitters and unique carbon sources available in the brain. These pathogenic strategies displayed by this fungus might have evolved through its interactions with microbial predators in the environment.

Funding
This study was supported by the:
  • Xiaorong Lin , National Institutes of Health , (Award 1R01AI140719)
  • Joseph Heitman , Canadian Institute for Advanced Research (CIFAR) , (Award Fungal Kingdom: Threats & Opportunities)
  • Joseph Heitman , National Institute of Allergy and Infectious Diseases , (Award AI112595-04)
  • Yong-Sun Bahn , National Research Foundation, Ministry of Science and ICT of Korea , (Award 2018R1A5A1025077)
  • Yong-Sun Bahn , National Research Foundation, Ministry of Science and ICT of Korea , (Award 2016R1E1A1A01943365)
  • Yong-Sun Bahn , Strategic Initiative for Microbiomes in Agriculture and Food, Ministry of Agriculture, Food and Rural Affairs of Korea , (Award 918012-4)
  • Yong-Sun Bahn , Strategic Initiative for Microbiomes in Agriculture and Food, Ministry of Agriculture, Food and Rural Affairs of Korea , (Award 916006-2)
  • Joseph Heitman , National Institute of Allergy and Infectious Diseases , (Award AI50113-16)
  • Yong-Sun Bahn , National Institute of Allergy and Infectious Diseases , (Award AI39115-23)
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/content/journal/micro/10.1099/mic.0.000973
2020-09-21
2020-10-20
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