Two lines of evidence suggest that, unlike in other organisms, the transfer RNAs of undergo rapid turnover Firstly, the tRNA content of cells treated with rifampicin (an inhibitor of initiation of RNA synthesis) decreased rapidly and continuously. Secondly, the newly synthesized tRNAs were rapidly degraded even under normal conditions of growth; the average half life of tRNA was 11.8 min. The degradation is mediated by an enzyme(s), present in cytoplasm, that apparently degrades tRNA completely. Rapid turnover is balanced by an enhanced rate of tRNA biogenesis, which was calculated to be 2.5 times higher than that in

Keyword(s): transfer RNA and Vibrio cholerae

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