1887

Abstract

Summary: Mutants of resistant to benzimidazole fungicides varied in their responses to 2-(thiazol-4-yl)benzimidazole (thiabendazole, TBZ), methyl I-(butylcarbamoyl)-benzimidazol-2-yl carbamate (benomyl) and methyl benzimidazol-2-yl carbamate (carbendazim, MBC). Incorporation of [C]MBC into trichloroacetic acid extracts of the sensitive strain S increased during a 2 h incubation period, whereas incorporation into the resistant mutant M55 was unchanged. [C]MBC uptake by S4 cells was five times higher than that by M55. MBC was identified as the main radioactive compound inside the S4 cells and reached a level of 2·4 g/100 mg dry wt.

The compound MBC enters the cells of by a temperature-, energy-, pH- and concentration-dependent transport system which may be specific for compounds containing a benzimidazole nucleus. It is suggested that tolerance of 55 to MBC is due to decreased permeability of the cell to this compound

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/content/journal/micro/10.1099/00221287-94-1-167
1976-05-01
2022-01-22
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