Bacteriocins produced by six strains of were found to be of the relatively low molecular weight, non-phage type. The molecular weights ranged from approximately 1.8 × 10 to 2.0 x 10. All were of protein composition, as indicated by buoyant density (1.32 to 1.34 g/cm) in CsCl and by sensitivity to proteolytic enzymes. They were resistant to RNAase but sensitive to DNAase. The six bacteriocins could further be separated into two subgroups on the basis of sensitivity to extremes of pH, binding to filter membranes, activity spectrum on sensitive strains of , and possibly mode of action on sensitive bacteria. Bacteriocin production ocfnred spontaneously during the early-to mid-exponential phase of bacterial growth in broth culture.


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