Summary: A lethal reaction followed fusion between plasmodia of two strains ( and ) of the Myxomycete on a solid medium. Dead areas were seen about 5 h after fusion and increased in size rapidly. Strain was often wholly destroyed but strain commonly survived and subsequently reinvaded the dead areas. Large plasmodia of were destroyed by fusion with small plasmodia of but large plasmodia of survived fusion with small plasmodia of The lethal reaction did not normally occur under conditions of suboptimal nutrition, but disappearance of strain still took place. It is suggested that protoplasm of strain can eliminate nuclei of strain but that strain has little or no ability to tolerate or eliminate nuclei of strain


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