1887

Abstract

Summary: The growth of several adenine-independent strains of yeasts in defined media containing suboptimal concentrations of biotin and relatively high concentrations of methionine is associated with the formation of a pink pigment in the cells and of an arylamine in the culture fluid. Under similar conditions, pigment and arylamine are not produced by an adenine-requiring strain of Culture filtrates containing arylamine promote the growth of in adenine-free medium, but an adenine-requiring lactobacillus responds only after a considerable lag. The results are interpreted to mean that the arylamine is, or is derived from, a precursor of adenine, whose conversion to adenine is impaired by deficiency of biotin.

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/content/journal/micro/10.1099/00221287-7-1-2-54
1952-08-01
2021-07-27
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References

  1. Analytical Methods Committee 1940; Report on the microbiological assay of riboflavin and nicotinic acid. Analyst 71397
    [Google Scholar]
  2. Bratton A.C., Marshall E.K. 1939; A new coupling component for sulphanil- amide determination. J. biol. Chem. 128:537
    [Google Scholar]
  3. Cutts N.S., Rainbow C. 1950a; Methionine and the formation of pigment by yeasts. Nature; Lond.: 1661117
    [Google Scholar]
  4. Cutts N.S., Rainbow C. 1950b; Studies of a yeast exacting towards p-amino- benzoie acid. J. gen. Microbiol. 4:150
    [Google Scholar]
  5. Lindegren C.C., Lindegren G. 1947; Depletion mutation in Saccharomyces. . Proc. nat. Acad. Sci., Wash. 33314
    [Google Scholar]
  6. Northam B.E., Norris F.W. 1951; Growth requirements of Schizosaccharo- myces octosporus, a yeast exacting towards adenine. J. gen. Microbiol. 5:502
    [Google Scholar]
  7. Rainbow C. 1948; Para-aminobenzoic acid a growth factor for certain brewer’s yeasts. Nature; Lond.: 162572
    [Google Scholar]
  8. Skive W., Ackermannt W.W., Gordon M., Getzendaner M.E., Eakin R.E. 1947; 5(4)-Amino-4(5)-imidazolecarboxamide, a precursor of purines. J. Amer. chem. Soc. 69:725
    [Google Scholar]
  9. Stetten M.R., Fox C.L. 1945; An amine formed by bacteria during sulphon- amide baeteriostasis. J. biol. Chem. 161:333
    [Google Scholar]
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