SUMMARY: The growth of several adenine-independent strains of yeasts in defined media containing suboptimal concentrations of biotin and relatively high concentrations of methionine is associated with the formation of a pink pigment in the cells and of an arylamine in the culture fluid. Under similar conditions, pigment and arylamine are not produced by an adenine-requiring strain of Culture filtrates containing arylamine promote the growth of in adenine-free medium, but an adenine-requiring lactobacillus responds only after a considerable lag. The results are interpreted to mean that the arylamine is, or is derived from, a precursor of adenine, whose conversion to adenine is impaired by deficiency of biotin.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error