Summary: The growth of a range of Gram-positive bacteria was inhibited by organo-chlorine insecticides while that of Gram-negative organisms was unaffected. Growing cultures of (ATCC 9372) treated with 20 p.p.m. technical chlordane ceased to grow and showed a decline in viable count and respiration rate, both being eliminated after about 3 h. A delayed release of incorporated L-[U-C]leucine and L-malate dehydrogenase occurred concomitant with a fall of . It is suggested that these phenomena are a result of disruption of membrane-associated metabolism, including electron transport and cell wall biosynthesis, which leads to cell lysis. No effect on these parameters occurred with growing cultures of (ATCC 8739). The chlordane sensitivity of succinate oxidation by sphaeroplasts of indicates that the intact cell wall prevents penetration of pesticide to sensitive sites within the walls of Gram-negative bacteria.


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