SUMMARY: Inability of the L-phase of Gram-positive bacteria to persist is explainable by its need for osmotic protection. Adaptation to physiological osmotic conditions did not enhance the ability of the L-phase to survive after intravenous or intraperitoneal injection in mice. One ‘low-salt’ L-strain survived in mice for 8 days when protected against phagocytosis by a filter box, whereas under the same conditions its ‘high-salt’ parent L-strain died in a few hours. The decrease of the number of surviving colony-forming units of this low-salt L-strain in the filter box contrasts sharply with the increase in number shown by the parent bacterial strain protected in the same way.


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