1887

Abstract

Surmmary

Radioactive incorporation techniques have been employed to investigate the effect of isonicotinic acid hydrazide (INH) on biosynthetic reactions in var. BCG. INH has no measurable effect on incorporation of P phosphate, S sulphate or C glycine into whole cells, although it inhibits by 50% the incorporation of C acetate. Incorporation of P into trichloracetic acid (TCA) insoluble components of supernatant solutions from centrifuged disrupted bacteria appears to be inhibited soon after the cells are exposed to INH. Similar experiments with S show a lag of 30–40 hr before incorporation is influenced by the drug. Chemical fractionation of organisms grown in the presence of P show that the major effect of INH is exerted on incorporation into the ribonucleic acid fraction.

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/content/journal/micro/10.1099/00221287-47-3-379
1967-06-01
2020-12-03
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-47-3-379
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