1887

Abstract

SUMMARY: Tetrachlorsalicylanilide (TCS) is a skin germicide which is bacteriostatic for Gram-positive bacteria at low concentrations and bactericidal at high concentrations; both activities are dependent on inoculum size and are not specific to a particular growth phase. Glucose oxidation by was inhibited at TCS1 μg./ml. whereas 20 μg./ml. was required to inhibit glucose fermentation. treated with TCS which released amino acids did not accumulate C-labelled 1-glutamic acid, 1-lysine, 1-aspartic acid or sodium succinate. Inhibition by TCS of these processes as well as bacteriostasis was annulled by subsequent treatment with normal horse serum.

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1966-09-01
2022-01-24
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