Biochemical mutants of were isolated and tested for their capacity to produce actinomycin. The yield of actinomycin produced in minimal medium plus the required amino acid, by strains requiring an amino acid not present in the molecule of actinomycin, was not significantly different from that obtained from the wild-type strain. On the other hand, all the strains which required an amino acid, which was also a precursor of the antibiotic, showed on minimal medium a drastic decrease in the production of actinomycin. The results have been interpreted by assuming a different utilization by the cell of exogenous and endogenous amino acid pools for antibiotic and protein synthesis.


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