RT Journal Article SR Electronic(1) A1 POLSINELLI, M. A1 ALBERTINI, A. A1 CASSANI, G. A1 CIFERRI, O.YR 1965 T1 Relation of Biochemical Mutations to Actinomycin Synthesis in Streptomyces antibioticus JF Microbiology, VO 39 IS 2 SP 239 OP 246 DO https://doi.org/10.1099/00221287-39-2-239 PB Microbiology Society, SN 1465-2080, AB SUMMARY Biochemical mutants of Streptomyces antibioticus were isolated and tested for their capacity to produce actinomycin. The yield of actinomycin produced in minimal medium plus the required amino acid, by strains requiring an amino acid not present in the molecule of actinomycin, was not significantly different from that obtained from the wild-type strain. On the other hand, all the strains which required an amino acid, which was also a precursor of the antibiotic, showed on minimal medium a drastic decrease in the production of actinomycin. The results have been interpreted by assuming a different utilization by the cell of exogenous and endogenous amino acid pools for antibiotic and protein synthesis., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-39-2-239