Summary: Propagated on a group II host, phage 3C behaves as a typical group II phage; but after passage on hosts of wide group patterns, 1 and 73, 3C phage is host-restricted, losing its potential for infecting group II hosts and gaining an increased potential for infecting group III hosts. Such a phage would be considered a group III phage. The change occurs in the first burst of every infected cell. The phage released retains its A serology. Phage 3C can be propagated directly on several group III cocci and in these hosts a similar host-restriction occurs. These observations constitute evidence that host-induced modifications can alter the group lytic spectrum of a specific typing phage.


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