@article{mbs:/content/journal/micro/10.1099/00221287-36-1-25, author = "Ralston, Doris J. and Baer, Beatrice S.", title = "Host-controlled Changes of Staphylococcal Phage 3C Affecting its Broad Group Typing Pattern", journal= "Microbiology", year = "1964", volume = "36", number = "1", pages = "25-36", doi = "https://doi.org/10.1099/00221287-36-1-25", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-36-1-25", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "Summary: Propagated on a group II host, phage 3C behaves as a typical group II phage; but after passage on hosts of wide group patterns, Staphylococcus aureus k1 and 73, 3C phage is host-restricted, losing its potential for infecting group II hosts and gaining an increased potential for infecting group III hosts. Such a phage would be considered a group III phage. The change occurs in the first burst of every infected cell. The phage released retains its A serology. Phage 3C can be propagated directly on several group III cocci and in these hosts a similar host-restriction occurs. These observations constitute evidence that host-induced modifications can alter the group lytic spectrum of a specific typing phage.", }