SUMMARY: The yields of three antigens of (fraction I, antigen 4, V antigen) in continuous flow culture over a range of temperature and pH values have been determined quantitatively. The production of some other antigens was followed qualitatively. The production of fraction I, V antigen and antigen 4 was greatest at 37° and little or none at 28° The production of antigen 4 required an environmental pH below 6.9. The production of antigen 5 showed oxygen dependence at 28° but not at 37° In transitions from one antigenic state to another the amounts of some antigens in the organism passed through maxima. Selection against types with the V and fraction I antigens occurred during growth at 37°, but not at 28°. Selection against types with antigen 4 did not occur.


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