RT Journal Article SR Electronic(1) A1 Pirt, S. J. A1 Thackeray, E. J. A1 Harris-Smith, R.YR 1961 T1 The Influence of Environment on Antigen Production by Pasteurella pestis Studied by Means of the Continuous Flow Culture Technique JF Microbiology, VO 25 IS 1 SP 119 OP 130 DO https://doi.org/10.1099/00221287-25-1-119 PB Microbiology Society, SN 1465-2080, AB SUMMARY: The yields of three antigens of Pasteurella pestis (fraction I, antigen 4, V antigen) in continuous flow culture over a range of temperature and pH values have been determined quantitatively. The production of some other antigens was followed qualitatively. The production of fraction I, V antigen and antigen 4 was greatest at 37° and little or none at 28°. The production of antigen 4 required an environmental pH below 6·9. The production of antigen 5 showed oxygen dependence at 28° but not at 37°. In transitions from one antigenic state to another the amounts of some antigens in the organism passed through maxima. Selection against types with the V and fraction I antigens occurred during growth at 37°, but not at 28°. Selection against types with antigen 4 did not occur., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-25-1-119