SUMMARY: A new gene, , is described in . This gene is shown to be a modifier of the nutritional response of strains containing the gene, and is not nutritionally detectable in the absence of the mutant locus. The gene is additionally characterized by a decreased ability to synthesize thiamine from thiazole and pyrimidine; appears to modify only strains because of their unusually high thiamine requirements. The nutritional responses of strains containing either or loci are not affected by the presence of . Both and are anomalous in the condensation of pyrimidine and thiazole. The probability that may be an isoallele of is based upon a similarity of metabolic pattern and upon location on chromosome III. The failure to obtain recombination in crosses between strains containing and constitutes additional support for their allelism.


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