1887

Abstract

Summary: A new gene, is described in This gene is shown to be a modifier of the nutritional response of strains containing the gene, and is not nutritionally detectable in the absence of the mutant locus. The gene is additionally characterized by a decreased ability to synthesize thiamine from thiazole and pyrimidine; appears to modify only strains because of their unusually high thiamine requirements. The nutritional responses of strains containing either or loci are not affected by the presence of Both and are anomalous in the condensation of pyrimidine and thiazole. The probability that may be an isoallele of is based upon a similarity of metabolic pattern and upon location on chromosome III. The failure to obtain recombination in crosses between strains containing and constitutes additional support for their allelism.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-20-1-43
1959-02-01
2021-10-21
Loading full text...

Full text loading...

/deliver/fulltext/micro/20/1/mic-20-1-43.html?itemId=/content/journal/micro/10.1099/00221287-20-1-43&mimeType=html&fmt=ahah

References

  1. Barratt R.W., Newmeyer D., Perkins D.D., Garnjobst L. 1954; Map construction in Neurospora crassa. . Advanc. Genet. 5:1
    [Google Scholar]
  2. Beadle G.W., Tatum E.L. 1945; Neurospora II. Methods of producing and detecting mutations concerned with nutritional requirements. Amer. J. Bot. 32:678
    [Google Scholar]
  3. Eberhart B.M. 1956; The Biochemical Genetics of Thiamine Metabolism in Neuro-spora crassa. Doctoral thesis Stanford University:
    [Google Scholar]
  4. Giles N.H. 1955; Forward and back mutation in specific loci in Neurospora. . Brookhaven Symp. Biol. 8:103
    [Google Scholar]
  5. Goldschmidt R.B., Piternick L.K. 1956; New experiments on chemical phenocopies. Proc. nat. Acad. Sci., Wash. 42:299
    [Google Scholar]
  6. Harris D.L. 1953; Biosynthesis of thiamine in Neurospora. . Fed. Proc. 12:214
    [Google Scholar]
  7. Harris D. L. 1955; Alternative pathways in thiamine biosynthesis in Neurospora. . Arch. Biochem. Biophys. 57:240
    [Google Scholar]
  8. Haskins F.A., Mitchell H.K. 1952; An example of modifying genes in Neurospora. . Amer. Nat. 86:231
    [Google Scholar]
  9. Houlahan M.B., Mitchell H.K. 1947; A suppressor in Neurospora and its use as evidence for allelism. Proc. nat. Acad. Sci., Wash. 33:223
    [Google Scholar]
  10. Newmeyer D., Tatum E.L. 1953; Gene expression in Neurospora mutants requiring nicotinic acid or tryptophan. Amer. J. bot. 40:392
    [Google Scholar]
  11. Stiller E.T. 1950 In Vitamin Methods i p. 95 Gyorgy P. ed. New York: Academic Press, Inc.;
    [Google Scholar]
  12. Strauss B.S. 1956; The nature of the lesion in the succinate requiring mutants of Neurospora crossa: interaction between carboxylase and nitrogen metabolism. J. gen. Microbiol. 14:494
    [Google Scholar]
  13. Tatum E.L., Bell T.T. 1946; Neurospora. III. Biosynthesis of thiamin. Amer. J. Bot. 33:15
    [Google Scholar]
  14. Westenbrink H.G.K., Steyn-Parvé E.P. 1950; Methods for the determination of diphosphothiamine. Z. Vitaminforsch. 21:461
    [Google Scholar]
  15. Westergaard M., Mitchell J.K. 1947; Neurospora. V. A synthetic medium favouring sexual reproduction. Amer. J. Bot. 34:573
    [Google Scholar]
  16. Yanofsky C. 1956; Gene interactions in enzyme synthesis. In Enzymes, Units of Biological Structures and Function p. 147 Gaebler O. H. ed. New York: Academic Press;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-20-1-43
Loading
/content/journal/micro/10.1099/00221287-20-1-43
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error