The sensitivity of 4 strains of and of when growing under aerobic and under anaerobic conditions in heavily buffered enriched medium was compared. Each comparison covered a series of pH values from 5·5 to 8·0. A distinct pattern emerged for each group of organisms and this would appear to be related to the enzymic make-up of the organism with respect to carbohydrate metabolism and not to the pH developed in the medium during growth or to the growth rate of the organism. Comparison of the behaviour of under identical conditions, but in a simple medium, suggests that dihydrostreptomycin is more effective against synthesizing than against energy-producing mechanisms.


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