1887

Abstract

Munumbicins A, B, C and D are newly described antibiotics with a wide spectrum of activity against many human as well as plant pathogenic fungi and bacteria, and a sp. These compounds were obtained from NRRL 3052, which is endophytic in the medicinal plant snakevine (), native to the Northern Territory of Australia. This endophyte was cultured, the broth was extracted with an organic solvent and the contents of the residue were purified by bioassay-guided HPLC. The major components were four functionalized peptides with masses of 12696, 12985, 13125 and 13265 Da. Numerous other related compounds possessing bioactivity, with differing masses, were also present in the culture broth extract in lower quantities. With few exceptions, the peptide portion of each component contained only the common amino acids threonine, aspartic acid (or asparagine), glutamic acid (or glutamine), valine and proline, in varying ratios. The munumbicins possessed widely differing biological activities depending upon the target organism. For instance, munumbicin B had an MIC of 25 μg ml against a methicillin-resistant strain of , whereas munumbicin A was not active against this organism. In general, the munumbicins demonstrated activity against Gram-positive bacteria such as and multidrug-resistant . However, the most impressive biological activity of any of the munumbicins was that of munumbicin D against the malarial parasite , having an IC of 45±007 ng ml. This report also describes the potential of the munumbicins in medicine and agriculture.

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2002-09-01
2020-04-08
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