1887

Microbiology

Volume 148, Issue 3

Detection and mutation of a -encoded autoinducer in Free

Abstract

Quorum sensing regulates the expression of virulence factors in a wide variety of pathogenic bacteria. This study has shown that harbours a homologue of , a gene required for the synthesis of the quorum sensing autoinducer 2 (AI-2). AI-2 activity is expressed during and is correlated with the initiation of swarming migration on agar surfaces. The locus was cloned and a LuxS strain constructed by allelic-exchange mutagenesis. While lacking AI-2 activity, a null mutation in , however, did not affect swimming or swarming motility, swarmer cell differentiation, or virulence in a mouse model of ascending urinary tract infection.

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  • Accepted:
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  • Published Online:
Keyword(s): AHL, N-acylhomoserine lactone , AI, autoinducer , LuxS , quorum sensing , swarming , urinary tract infection , UTI, urinary tract infection and virulence
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2002-03-01
2019-08-20

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Detection and mutation of a luxS-encoded autoinducer in Proteus mirabilis
Microbiology 148, 773 (2002); https://doi.org/10.1099/00221287-148-3-773
/content/journal/micro/10.1099/00221287-148-3-773
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