@article{mbs:/content/journal/micro/10.1099/00221287-148-3-773, author = "Schneider, Rachel and Lockatell, C. Virginia and Johnson, David and Belas, Robert", title = "Detection and mutation of a luxS-encoded autoinducer in Proteus mirabilisThe GenBank accession number for the sequence reported in this paper is AY044337.", journal= "Microbiology", year = "2002", volume = "148", number = "3", pages = "773-782", doi = "https://doi.org/10.1099/00221287-148-3-773", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-148-3-773", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", keywords = "AI, autoinducer", keywords = "quorum sensing", keywords = "urinary tract infection", keywords = "AHL, N-acylhomoserine lactone", keywords = "LuxS", keywords = "virulence", keywords = "swarming", keywords = "UTI, urinary tract infection", abstract = "Quorum sensing regulates the expression of virulence factors in a wide variety of pathogenic bacteria. This study has shown that Proteus mirabilis harbours a homologue of luxS, a gene required for the synthesis of the quorum sensing autoinducer 2 (AI-2). AI-2 activity is expressed during and is correlated with the initiation of swarming migration on agar surfaces. The P. mirabilis luxS locus was cloned and a LuxS− strain constructed by allelic-exchange mutagenesis. While lacking AI-2 activity, a null mutation in luxS, however, did not affect swimming or swarming motility, swarmer cell differentiation, or virulence in a mouse model of ascending urinary tract infection.", }