Two genomic fragments have been isolated from which strongly hybridize to an essential gene which encodes GDP-mannose pyrophosphorylase in A common 2.5 kb fragment has been identified, which Southern analysis suggests is most likely unique in the genome. The fragment contains an ORF, which is 82% identical and 90% homologous to the Srb1p/Psa1p/Vig9p from contains one additional amino acid at position 254 and is able to functionally complement the major phenotypic characteristics of null and conditional mutations. The authors therefore conclude that they have cloned and sequenced from the bona fide homologue of named hereafter Northern analysis data indicate that the gene is expressed in under conditions of growth in the yeast and hyphal form and suggest that its expression might be regulated.


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