Summary: In this study a description is given of the sequence and analysis of 52 kb from the 1.1 Mb genome of , a member of the α-Proteobacteria. An investigation was made of nucleotide frequencies and amino acid composition patterns of 41 coding sequences, distributed in 10 genomic contigs, of which 32 were found to have putative homologues in the public databases. Overall, the coding content of the individual contigs ranged from 59 to 97%, with a mean of 81%. The genes putatively identified included genes involved in the biosynthesis of nucleotides, macromolecules and cell wall structures as well as citric acid cycle component genes. In addition, a putative identification was made of a member of the regulatory response family of two-component signal transduction systems as well as a gene encoding haemolysin. For one gene, the homologue of , an internal stop codon was discovered within a region that is otherwise highly conserved. Comparisons with the genomic structures of and have revealed several atypical gene organization patterns in the genome. For example, was found to have a unique arrangement of genes upstream of in a region that is highly conserved among other microbial genomes and thought to represent the origin of replication of a primordial replicon. The results presented in this paper support the hypothesis that the genome is a highly derived genome and provide examples of gene order structures that are unique for the


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