1887

Abstract

Summary: Nisin production by subsp. NIZO 22186 was studied in batch fermentation using a complex medium. Nisin production showed primary metabolite kinetics: nisin biosynthesis took place during the active growth phase and completely stopped when cells entered the stationary phase. A stringent correlation could be observed between the expression of the prenisin gene () and the synthesis of the post-translationally enzymically modified and processed mature nisin peptide. Moreover, it seemed likely that nisin had a growth control function. A physiological link is proposed between sucrose fermentation capacity and nisin production ability. Carbon source regulation appears to be a major control mechanism for nisin production.

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/content/journal/micro/10.1099/00221287-138-3-571
1992-03-01
2019-10-24
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-138-3-571
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