@article{mbs:/content/journal/micro/10.1099/00221287-138-3-571, author = "DE VUYST, LUC and VANDAMME, ERICK J.", title = "Influence of the carbon source on nisin production in Lactococcus lactis subsp. lactis batch fermentations", journal= "Microbiology", year = "1992", volume = "138", number = "3", pages = "571-578", doi = "https://doi.org/10.1099/00221287-138-3-571", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-138-3-571", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "Summary: Nisin production by Lactococcus lactis subsp. lactis NIZO 22186 was studied in batch fermentation using a complex medium. Nisin production showed primary metabolite kinetics: nisin biosynthesis took place during the active growth phase and completely stopped when cells entered the stationary phase. A stringent correlation could be observed between the expression of the prenisin gene (nisA) and the synthesis of the post-translationally enzymically modified and processed mature nisin peptide. Moreover, it seemed likely that nisin had a growth control function. A physiological link is proposed between sucrose fermentation capacity and nisin production ability. Carbon source regulation appears to be a major control mechanism for nisin production.", }