1887

Abstract

The effects of intracerebral and intravenous infection on experimental meningo-encephalitis in mice were compared. Naive mice inoculated with two strains of different pathogenicity (highly virulent CA-6 and poorly virulent PCA-2) were more resistant to infection when the yeasts were inoculated by the intracerebral rather than the intravenous route. In immunized mice, in which systemic immunity had been induced by long-term colonization with low-virulence PCA-2 cells, increased intracerebral resistance to challenge with virulent was observed at about two weeks post-infection. In contrast, the inoculation of PCA-2 cells directly into the brain resulted in early, long-lasting activation of local microbicidal mechanisms against intracerebral challenge with CA-6, or . Increased local anti- resistance was also observed upon intracerebral injection of human recombinant interleukin 1. These data suggest that, in addition to the intracerebral expression of systemic antifungal immunity, microbial mechanisms may be locally activated in the brain, possibly through release of endogenous interleukin 1.

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1991-08-01
2024-12-02
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References

  1. Blstoni F., Vecchiarelli A., Mazzolla R., Puccetti P., Marconi P., Garaci E. 1985; Immunoadjuvant activity of amphotericin B as displayed in mice infected with Candida albicans . Antimicrobial Agents and Chemotherapy 27:625–631
    [Google Scholar]
  2. Bistoni F., Vecchiarelli A., Cenci E., Puccetti P., Marconi P., Cassone A. 1986; Evidence for macrophage-mediated protection against lethal Candida albicans infection. Infection and Immunity 51:668–674
    [Google Scholar]
  3. Bistoni F., Verducci G., Perito S., Vecchiarelli A., Puccetti P., Marconi P., Cassone A. 1988; Immunomodulation by a low-virulence, agerminative variant of Candida albicans Further evidence for macrophage activation as one of the effector mechanisms of nonspecific anti-infectious protection. Journal of Medical and Veterinary Mycology 26:285–299
    [Google Scholar]
  4. Cantorna M. T., Balish E. 1990; Mucosal and systemic candidiasis in congenitally immunodeficient mice. Infection and Immunity 58:1093–1100
    [Google Scholar]
  5. Cenci E., Romani L., Vecchiarelli A., Puccetti P., Bistoni F. 1989; Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice. Infection and Immunity 57:3581–3587
    [Google Scholar]
  6. Cenci E., Romani L., Vecchiarelli A., Puccetti P., Bistoni F. 1990; T cell subsets and IFN-’y production in resistance to systemic candidosis in immunized mice. Journal of Immunology 144:4333–4339
    [Google Scholar]
  7. Domer J. E. 1988; Intragastric colonization of infant mice with Candida albicans induces systemic immunity demonstrable upon challenge as adults. Journal of Infectious Diseases 157:950–958
    [Google Scholar]
  8. Giulian D. 1987; Ameboid microglia as effectors of inflammation in the central nervous system. Journal of Neuroscience Research 18:155–171
    [Google Scholar]
  9. Giulian D., Young D. G., Woodward J., Brown D. C., Lachman L. B. 1988; Interleukin-1 is an astroglial growth factor in the developing brain. Journal of Neuroscience 8:709–714
    [Google Scholar]
  10. Hetier F., Ayala J., Denèfle P., Bousseau A., Rouget P., Mallat M., Prochiantz A. 1988; Brain macrophages synthesize interleukin-1 and interleukin-1 mRNAs in vitro . Journal of Neuroscience Research 21:391–397
    [Google Scholar]
  11. Khardori N. 1989; Host-parasite interaction in fungal infections. European Journal of Clinical Microbiology and Infectious Diseases 8:331–351
    [Google Scholar]
  12. Klein R. S., Harris C. A., Small C. B., Moll B., Lesser M., Friedland G. H. 1984; Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. New England Journal of Medicine 311:354–358
    [Google Scholar]
  13. Kullberg B. J., Van’t Wout J. W., Van Furto R. 1990; Role of granulocytes in increased host resistance to Candida albicans induced by recombinant interleukin-1. Infection and Immunity 58:3319–3324
    [Google Scholar]
  14. Lipton S. A., Hickey W. F., Morris J. H., Loscalzo J. 1984; Candidai infection in the central nervous system. American Journal of Medicine 16:101–108
    [Google Scholar]
  15. Murphy J. W. 1990; Immunity to fungi. Current Opinion in Immunology 2:360–367
    [Google Scholar]
  16. Odds F. C. 1988 Candida and Candidosis, 2. London: Baillière Tindall;
    [Google Scholar]
  17. Pendlebury W. W., Perl D. P., Munoz D. G. 1989; Multiple microabscesses in the central nervous system: a clinicopathologic study. Journal of Neuropathology and Experimental Neurology 48:290–300
    [Google Scholar]
  18. Perry V. H., Gordon S. 1988; Macrophages and microglia in the nervous system. Trends in Neuroscience 11:273–277
    [Google Scholar]
  19. Rogers T. J., Balish E. 1980; Immunity to Candida albicans . Microbiological Reviews 44:660–682
    [Google Scholar]
  20. Romani L., Fioretti M. C., Bianchi R., Nardelli B., Bonmassar E. 1982; Intracerebral adoptive immunotherapy of a murine lymphoma antigenically altered by drug treatment in vivo. Journal of the National Cancer Institute 68:817–822
    [Google Scholar]
  21. Van’t Wout J. W., Van der Meer J. W. M., Barza M., Dinarello C. A. 1988; Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin 1. European Journal of Immunology 18:1143–1146
    [Google Scholar]
  22. Vecchiarelli A., Mazzolla R., Farinelli S., Cassone A., Bistoni F. 1988; Immunomodulation by Candida albicans crucial role of organ colonization and chronic infection with an attenuated agerminative strain of C. albicans for establishment of anti-infectious protection. Journal of General Microbiology 134:2583–2592
    [Google Scholar]
  23. Vecchiarelli A., Cenci E., Puliti M., Blasi E., Puccetti P., Cassone A., Bistoni F. 1989; Protective immunity induced by low-virulence Candida albicans : cytokine production in the development of the anti-infectious state. Cellular Immunology 124:334–344
    [Google Scholar]
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