Summary: The macrolide antibiotic erythromycin is produced by different genera of the , including strains of and possibly . Erythromycin is also produced by several unclassified strains, four of which could be assigned to the genus on the basis of bacteriophage host specificity. We used cloned erythromycin biosynthetic and resistance genes from as hybridization probes to determine if the DNA sequences encoding these genes are conserved in different genera. Our results indicated strong hybridization to genomic restriction fragments from strains that were assigned to the genus , and weak hybridization to DNA from strains which produce erythromycin or other macrolides but belong to other genera.


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