SUMMARY: , the regulatory gene of the cysteine regulon, is autoregulated. Inhibitors of both gyrase subunits, nalidixic acid and novobiocin, affect the expression of , as monitored by β-galactosidase activity in :: fusion strains. In mutants that are resistant to nalidixic acid, this drug does not affect expression. The amount of mRNA transcribed from the promoter isolated from cultures grown in the presence of gyrase inhibitors was significantly lower than that from the control culture without inhibitors. Urea also decreased expression. These results suggest that DNA topology could play a role in expression.


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