Summary: Synthesis of alkaline phosphatase in , unlike that of the two molecular forms of acid phosphatase, is not controlled by inorganic phosphate in the culture medium. The nature of the carbon source seems to play an important role in the regulation of this enzyme. Growth on a fermentable carbon source such as glucose, fructose or mannose leads to a constitutive synthesis of the enzyme which stops as soon as the sugar is exhausted, even though the yeast continues to grow on the products of the sugar fermentation. On transfer of cells from a glucose-containing to an ethanol-containing medium alkaline phosphatase synthesis stops immediately, whereas synthesis of the enzyme starts immediately on transfer of cells from an ethanol-containing to a glucose-containing medium. Transfer to growth on a different carbon source has no effect on the synthesis of the two forms of acid phosphatase. Thus, it seems that synthesis of acid and alkaline phosphatase in is regulated by completely different mechanisms.


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