Mitochondrial adenosine triphosphatase (ATPase) of the ciliate protozoon ST is completely inhibited by antiserum prepared against F-ATPase purified from , and by naturally occurring inhibitor proteins from this yeast and from bovine heart mitochondria. An ATPase inhibitor protein is also present in extracts of Mitochondrial ATPase of is only partially inhibited by the F-ATPase inhibitors '-dicyclohexylcarbodiimide, oligomycin, leucinostatin, triethyltin sulphate and venturicidin, and (at high titres) by the F-ATPase inhibitors Dio-9, efrapeptin, 4-chloro-7-nitrobenzofurazan and spegazzinine. Aurovertin, citreoviridin and quercetin were not inhibitory. Resistance to inhibitors distinguishes this mitochondrial ATPase from all those previously examined.


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